Professor Karel Pacák established a nationally and internationally recognised research programme focusing on patients with pheochromocytoma and paraganglioma (PPGL) at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health (NIH) in Bethesda, Maryland. Over the past 25 years, his laboratory there has produced groundbreaking scientific findings and publications in this field.
Professor Pacák is a co-founder of the International Symposium on Pheochromocytoma (ISP), a series of international conferences that have fostered exceptional collaboration between the United States and other countries. In 2005, he served as the first president of the ISP and was re-elected to this post in 2022. He has played a significant role in expanding international collaboration in this field through his involvement with the Alliance for Pheochromocytoma and Paraganglioma, the Asian Alliance for the Study of Neuroendocrine Tumours, PRESSOR (Pheochromocytoma Research and Support Organisation), the Working Group on Endocrine Hypertension, the European Society of Hypertension and the American-Australian-Asian Adrenal Alliance (A5).
In 2012, Professor Pacák, together with others, supported and championed the Cancer Genome Atlas (TCGA) for pheochromocytoma within the National Cancer Institute (NCI) at the NIH, which to this day remains one of the most extensive molecular biological studies of this disease at both national and international level. Professor Pacák is one of the most frequently cited scientists in the field of pheochromocytoma and paraganglioma, with his work receiving more than 4,000 citations annually. He has received a number of prestigious awards for his contributions to endocrinology and oncology.
Education:
- 1984: First Faculty of Medicine, Charles University, Prague, Czech Republic, MUDr., general medicine (Summa cum laude)
- 1987: First Faculty of Medicine, Charles University, Third Department of Internal Medicine, Prague, Czech Republic, specialist qualification in internal medicine
- 1993: First Faculty of Medicine, Charles University, Prague, Czech Republic, PhD (formerly CSc.), neuroendocrinology
- 1998: MedStar Washington Hospital Center, Washington, DC, USA, specialist qualification in medicine
- 1999: National Institutes of Health, Bethesda, Maryland, USA, specialist qualification in endocrinology, diabetes and metabolism
- 1999: First Faculty of Medicine, Charles University, Third Department of Internal Medicine, Prague, Czech Republic, specialist qualification in endocrinology
- 1999: First Faculty of Medicine, Charles University, Third Department of Internal Medicine, Prague, Czech Republic, DSc, neuroendocrinology
- 2015: American Association of Clinical Endocrinology (AAC): American College of Endocrinology, Jacksonville, Florida, USA, FACE, endocrinology
- 2015: Palacký University, Olomouc, Czech Republic, Doctor honoris causa (Dhc)
Professional experience:
- 1984–1987: First Faculty of Medicine, Charles University, Third Department of Internal Medicine, Resident
- 1987–1990: First Faculty of Medicine, Charles University, Clinical and Research Fellow
- 1990–1995: National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, Maryland, USA, Research Fellow
- 1995–1997: Department of Medicine, MedStar Washington Hospital Centre, Washington, DC, USA, Resident in the internal medicine training programme
- 1997–1999: Inter-Institute Endocrinology Training Programme in Endocrinology, Diabetes and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA, Clinical Fellow
- 1999–2000: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA, Manager
- 2000–2005: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA, Head of the Department of Clinical Neuroendocrinology
- 2003–2005: First Faculty of Medicine, Charles University, External Associate Professor
- 2005–2008: Georgetown University, Washington, DC, USA, Visiting Professor
- 2005–2024: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA, Senior Clinical and Research Fellow, Department of Medical Neuroendocrinology
- 2006–present: First Faculty of Medicine, Charles University, Professor
- 2015–2024: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA, Manager of the Developmental Endocrinology and Tumour Genetics Group
- 2016–present: American College of Endocrinology, Jacksonville, Florida, USA, Member
- 2019–2024: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA, Manager of the Developmental Endocrinology, Metabolism, Genetics and Endocrine Oncology Group
- 2024–present: Department of Medicine, University of Florida, Gainesville, Florida, USA, Visiting Professor
- 2024–present: Centre for Adrenal Endocrine Tumours, AKESO POLICLINIC, Medical Director
- 2024–present: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA, Honorary Research Fellow Emeritus
Major awards:
- 1984: Rector’s Award, Charles University, for outstanding academic and research achievements, Charles University, Prague, Czechoslovakia
- 2007: Peter Heimann Memorial Award, International Association of Endocrine Surgeons
- 2007: NIH Director Mentoring Award, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA
- 2009: NICHD/NIH Director’s Award of Merit, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA
- 2014: NICHD/NIH Director’s Award of Merit, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA
- 2015: Outstanding Clinical Endocrinologist, American Association of Clinical Endocrinology (AACE), Jacksonville, Florida, USA
- 2016: Henry Friesen Award, Canadian Society of Endocrinology and Metabolism, Ottawa, Canada
- 2018: Jan Evangelista Purkyně Medal, Czech Medical Society, Prague, Czech Republic
- 2022: Outstanding Clinical Investigator Award, US Endocrine Society, Washington, DC, USA
- 2022: Frontiers in Science and Distinction in Endocrinology Award, American Association of Clinical Endocrinology (AACE), Jacksonville, Florida, USA
- 2024: Foreign Member, Learned Society of the Czech Republic